Akiko Yagi (Professor)
Mail Address
yagi.akiko at itbm.nagoya-u.ac.jp
or
yagi.akiko.r4 at f.mail.nagoya-u.ac.jp
Comment
I love “Chem is try”!
Education and Experience
2025- Professor
Department of Chemistry, Graduate School of Science, Nagoya University
2023– Nanoscale Horizons (RSC), Community Board
2022– JST PRESTO researcher
2021–2025 Designated Associate Professor
Institute of Transformative bio-Molecules (ITbM), Nagoya University
2017–2020 Assistant Professor
Department of Chemistry, Graduate School of Science, Nagoya University
2016–2017 Postdoctoral Fellow (JSPS Overseas Research Fellowship)
Department of Chemistry, The Scripps Research Institute, USA (Prof. Ryan A. Shenvi)
2013–2016 PhD (doctor course) student
Department of Chemistry, Graduate School of Science, Nagoya University (Prof. Kenichiro Itami) PhD degree: March 2016
Visiting Student, April 2013–July 2013 (Prof. Cathleen M. Crudden, Queen’s University, Canada)
2011–2013 Master course graduate student
Department of Chemistry, Graduate School of Science, Nagoya University (Prof. Kenichiro Itami, Nagoya University) M.S. degree: March 2013
Visiting Student, April 2012–May 2012 (Prof. Ken-Tsung Wong, National Taiwan University, Taiwan)
2007–2011Undergraduate student
Department of Chemistry, School of Science, Nagoya University (Prof. Kenichiro Itami, Nagoya University) B.S. degree: March 2011
Publication
(40) Tsubasa Okumura, Daiki Imoto, Yuri Arachi, Akiko Yagi, Takehisa Maekawa*, Kenichiro Itami*
“Twelvefold Dearomative Esterification of (6,6)Carbon Nanobelt.”
Angew. Chem., Int. Ed. 2025, e202510544. DOI: 10.1002/anie.202510544
Press release (Japanese)
(39) 八木 亜樹子、河野 英也、天池 一真、伊丹 健一郎
『メチレン架橋シクロパラフェニレンの化学と展開』
有機合成化学協会誌, Vol. 83 (2025)8, No. 5, 446–454. DOI: 10.5059/yukigoseikyokaishi.83.446
(38) Yoshifumi Toyama, Akiko Yagi, Kenichiro Itami, Hideto Ito*
“Birch reductive arylation by mechanochemical anionic activation of polycyclic aromatic compounds”
Nature Commun. 2025, 16, 5044. DOI: 10.1038/s41467-025-60318-y
Press release (Japanese)
(37) Yoshifumi Toyama, Takumu Nakamura, Yushin Horikawa, Yuta Morinaka, Yohei Ono, Akiko Yagi, Kenichiro Itami, Hideto Ito*
“Rh-catalyzed mechanochemical transfer hydrogenation for the synthesis of periphery-hydrogenated polycyclic aromatic compounds”
Chem. Sci. 2025, 16, 9117-9124. DOI: 10.1039/d5sc01489a
Press release (Japanese)
(36) Atsushi Usami*, Hideya Kono, Vic Austen, Quan Manh Phung, Hiroki Shudo, Tomoki Kato, Hayato Yamada, Akiko Yagi, Kazuma Amaike, Kazuhiro Fujimoto*, Takeshi Yanai* and Kenichiro Itami*
“In-insect synthesis of oxygen-doped molecular nanocarbons”
Science 2025, 388(6751),1055-1061. DOI:
Press release (Japanese)
(35) Nobushige Kai, Hideya Kono, Timo Stünkel, Daiki Imoto, Riccardo Zanasi*b, Guglielmo Monaco, Francesco F. Summa, Lawrence T. Scott, Akiko Yagi* and Kenichiro Itami*
“Stable cationic nanobelts synthesized by chemical oxidation of methylene-bridged [6]cycloparaphenylene”
Chem. Sci. 2025, Advanced Article. DOI: 10.1039/D5SC01305D
Press release (Japanese)
(34) Hiroki Shudo, Philipp Wiesener, Elena Kolodzeiski, Kiichi Mizukami, Daiki Imoto, Harry Mönig*, Saeed Amirjalayer*, Hirotoshi Sakamoto, Henning Klaasen, Bart Jan Ravoo, Nobuo Kimizuka*, Akiko Yagi*, Kenichiro Itami*
“Thiophene-fused aromatic belts”
Nature Commun. 2025, 16, 1074. DOI: 10.1038/s41467-025-55896-w
Press release (Japanese)
(33) Daiki Imoto, Hiroki Shudo, Akiko Yagi*, Kenichiro Itami*
“A double-walled noncovalent carbon nanotube by columnar packing of nanotube fragments”
Angew. Chem., Int. Ed. 2024, e202413828. DOI: 10.1002/anie.202413828
(32) Konstantin Günther, Hideya Kono, Hiroki Shudo, Reika Isoda, Masayoshi Nakamura, Akiko Yagi*, Kazuma Amaike*, Kenichiro itami*
“Water-soluble aromatic nanobelt with unique cellular internalization”
Angew. Chem., Int. Ed. 2024, e202414645. DOI: 10.1002/anie.202414645
Press release (Japanese)
(31) Daiki Imoto, Hiroki Shudo, Kiichi Mizukami, Nobuo Kimizuka*, Akiko Yagi*, Kenichiro Itami*
“Synthesis and size-dependent properties of multiple sizes of chlorinated fluorocycloparaphenylenes”
Chem. Commun. 2024, accepted. DOI:10.1039/D4CC03336A
(30) Yoshifumi Toyama, Takaku Yoshihara, Hiroki Shudo, Hideto Ito, Kenichiro Itami*, Akiko Yagi*
“Synthesis of diamondoids through hydrogenation of adamantane-annulated arenes
Chem. Lett. 2024, 53, upad037. DOI: 10.1093/chemle/upad037
(29) Daiki Imoto, Akiko Yagi, Kenichiro Itami*
“Carbon Nanobelts: Brief History and Perspective”
Precis. Chem. 2023, 1, 516–523. DOI: 10.1021/prechem.3c00083
(28) Hisayasu Ishibashi, Manuel Rondelli, Hiroki Shudo, Takehisa Maekawa, Hideto Ito, Kiichi Mizukami, Nobuo Kimizuka,* Akiko Yagi,* Kenichiro Itami*
“Noncovalent modification of cycloparaphenylene by catenane formation using an active metal template strategy”
Angew. Chem., Int. Ed. 2023, e202310613 DOI: 10.1002/anie.202310613
Selected as a Hot Paper! Selected as a Frontispiece!
ChemRxiv 2023 DOI: 10.26434/chemrxiv-2023-3rq4x
Press release (Japanese) Press release (English)
(27) Hideya Kono, Yuanming Li, Riccardo Zanasi,* Guglielmo Monaco, Francesco F. Summa, Lawrence T. Scott, Akiko Yagi,* Kenichiro Itami*
“Methylene-bridged [6]-, [8]-, and [10]cycloparaphenylenes: Size-dependent properties and paratropic belt currents”
J. Am. Chem. Soc. 2023, 145, 8939–8946. DOI: 10.1021/jacs.2c13208
Press release (Japanese) Press release (English)
(26) Hiroki Shudo, Motonobu Kuwayama, Yasutomo Segawa, Akiko Yagi, Kenichiro Itami
“Half-substituted fluorocycloparaphenylenes with high symmetry: Synthesis, properties and derivatization to densely substituted carbon nanorings”
ChemRxiv 2023 DOI:10.26434/chemrxiv-2023-zsvnt
Chem. Commun. 2023 accepted. DOI: 10.1039/D3CC04887J
(25) Takaku Yoshihara, Hiroki Shudo, Akiko Yagi,* Kenichiro Itami*
“Adamantane-annulation to arenes: A simple strategy for property modulation of aromatic π-systems”
J. Am. Chem. Soc. 2023, 145, 11754–11763. DOI: 10.1021/jacs.3c02788
ChemRxiv 2023 DOI: 10.26434/chemrxiv-2023-1jsp4
Press release (Japanese)
Highlighted in Synfacts. Highlighted in Chem-Station “スポットライトリサーチ”
Synfacts 2023; 19(09): 0869 DOI: 10.1055/s-0042-1751980
(24) Nobushige Kai, Hideya Kono, Akiko Yagi,* Kenichiro Itami*
“Synthesis and properties of methylene-bridged [6]cyclo-2,6-naphthylene”
Synlett 2023, 18, in press. DOI: 10.1055/a-2009-8219
Special issue honoring Prof. Masahiro Murakami’s contributions to science
(23) Shusei Fujiki, Kazuma Amaike, Akiko Yagi,* and Kenichiro Itami*
“Synthesis, properties, and material hybridization of bare aromatic polymers enabled by dendrimer support”
Nature Commun. 2022, 13, 5358. DOI: 10.1038/s41467-022-33100-7
Highlighted in Chem-Station “スポットライトリサーチ”, 日経クロステック、Highlighted in ScienMag, EurekAlert!, Phys.org, True Viral News, Mirage News, Bioengineer.org, Swift Telecast.
(22) Iain A. Stepek, Mai Nagase, Akiko Yagi, Kenichiro Itami
“New paradigms in molecular nanocarbon science”
Tetrahedron 2022,119, accepted. Special issue for the 65th anniversary of Tetrahedron.
(21) Hiroki Shudo, Motonobu Kuwayama, Masafumi Shimasaki, Taishi Nishihara, Youhei Takeda, Takuya Kuwabara, Akiko Yagi, Yasutomo Segawa, Kenichiro Itami
“Perfluorocycloparaphenylenes”
Nature Commun. 2022, 13, 3713.
ChemRxiv, DOI 10.33774/chemrxiv-2021-7kd63
Highlighted in Chem-Station “スポットライトリサーチ” Highlighted in Chemical & Engineering News (ACS). Featured as Editors’ Highlights in Nature Commun.
(20) Hiroki Sato, Rie Suizu, Tomoki Kato, Akiko Yagi, Yasutomo Segawa, Kunio Awaga, Kenichiro Itami
“N-doped Nonalternant Aromatic Belt via a Six-fold Annulative Double N-Arylation”
Chem. Sci. 2022,13, Accepted Manuscript. ChemRxiv, DOI 10.26434/chemrxiv-2022-jqvv2
(19) Masahiko Yoshimura, Sojung F. Kim, Ryosuke Takise, Shuhei Kusano, Sakuya Nakamura, Masanori Izumi, Akiko Yagi, Kenichiro Itami, Shinya Hagihara
“Development of potent inhibitors for strigolactone receptor DWARF 14”
Chem. Commun. 2020, 56, 14917-14919.
(18) Chemical synthesis of carbon nanorings and nanobelts
Yuanming Li, Hideya Kono, Takehisa Maekawa, Yasutomo Segawa, Akiko Yagi, Kenichiro Itami
Acc. Mater. Res. 2021, 2, 681-691. DOI: 10.1021/accountsmr.1c00105
(17) Photo-induced arylation of carbazoles with aryldiazonium salts
Bumpei Maeda, Genki Mori, Yota Sakakibara, Akiko Yagi, Kei Murakami, Kenichiro Itami
Asian J. Org. Chem. 2021, 10, 1428-1431.
(16) A Non-alternant Aromatic Belt: Methylene-bridged [6]Cycloparaphenylene Synthesized from Pillar[6]arene
Yuanming Li, Yasutomo Segawa, Akiko Yagi, Kenichiro Itami
J. Am. Chem. Soc. 2020, 142, 12850-12856. DOI:10.1021/jacs.0c06007
ChemRxiv, DOI 10.26434/chemrxiv.12415166.
(15) Programmable Synthesis of Multiply Arylated Cubanes through C–H Metalation and Arylation
Ryo Okude, Genki Mori, Akiko Yagi*, Kenichiro Itami*
Chem. Sci. 2020, 11, 7672-7675. DOI: 10.1039/D0SC01909G
(14) Synthesis of Highly Twisted, Nonplanar Aromatic Macrocycles Enabled By Axially Chiral 4,5-Diphenylphenanthrene building block
Yuanming Li, Akiko Yagi, Kenichiro Itami, J. Am. Chem. Soc. 2020, 142, 3246-3253. DOI: 10.1021/jacs.9b13549
(13) Six-fold C–H Borylation of Hexa-peri-hexabenzocoronene
Mai Nagase, Kenta Kato, Akiko Yagi, Yasutomo Segawa, Kenichiro Itami, Beilstein J. Org. Chem. 2020, 16, 391-397.
(12) Ni-Catalyzed α-selective C–H Borylations of Naphthalene-based Aromatic Compounds
Toshiyuki Kamei, Soshi Nishino, Akiko Yagi, Yasutomo Segawa, Toyoshi Shimada, J. Org. Chem. 2019, 84, 14354-14359.
(11) Synthesis of Sterically Hindered 4,5-Diarylphenanthrenes via Acid-catalyzed Bisannulation of Benzenediacetaldehydes with Alkynes
Yuanming Li, Akiko Yagi, Kenichiro Itami Chem. Sci. 2019, 10, 5470-5475. DOI:10.1039/c9sc00334g
Highlighted in Chemical Science! https://www.rsc.org/news-events/journals-highlights/2019/may/a-challenging-synthesis/
(10) Armchair and Chiral Carbon Nanobelts: Scholl Reaction in Strained Nanorings
Akiko Yagi, Yasutomo Segawa, Kenichiro Itami Chem (Preview), 2019, 5, 746.
(9) Chemical Synthesis of Cycloparaphenylenes
Yasutomo Segawa, Akiko Yagi, Kenichiro Itami Phys. Sci. Rev. 2017, 2, 20160102.
(8) ”Synthesis and Properties of [8]-, [10]-, [12]-, and [16]Cyclo-1,4-naphthylenes”
Keishu Okada, Akiko Yagi, Yasutomo Segawa, Kenichiro Itami Chem. Sci. 2017, 8, 661.
(7) “Branch-Selective Hydroarylation: Iodoarene–Olefin Cross-Coupling”
Samantha A. Green, Jeishla L. M. Matos, Akiko Yagi, Ryan A. Shenvi J. Am. Chem. Soc. 2016, 138, 12779.
(6) “Simple, direct methods for formation of self-assembled N-heterocyclic carbene monolayers on gold and their application in bio-sensing”
Cathleen M. Crudden, J. Hugh Horton, Mina R. Narouz, Zhijun Li, Christene A. Smith, Kim Munro, Christopher J. Baddeley, Christian R. Larrea, Benedict Drevniok, Bheeshmon Thanabalasingam, Alastair B. McLean, Olena V. Zenkina, Iraklii I. Ebralidze, Zhe She, Heinz-Bernhard Kraatz, Nicholas J. Mosey, Lisa N. Saunders, Akiko Yagi Nature Communications, 2016, 7, 12654.
(5) “Chemical Synthesis of Cycloparaphenylenes”
Yasutomo Segawa, Akiko Yagi, Kenichiro Itami Chemistry of Carbon Nanostructures (Eds. K. Müllen, X. Feng), De Gruyter, 2016
(4) “A Theoretical Study on the Strain Energy of Carbon Nanobelts”
Yasutomo Segawa, Akiko Yagi, Hideto Ito, and Kenichiro Itami Org. Lett. 2016, 18, 1430.
(3) “Design and Synthesis of Carbon Nanotube Segments”
Yasutomo Segawa, Akiko Yagi, Katsuma Matsui, and Kenichiro Itami. Angew. Chem., Int. Ed. 2016, 55, 5136.
(2) “Synthesis and Properties of Cycloparaphenylene-2,7-pyrenylene: A Pyrene-containing Carbon Nanoring”
Akiko Yagi, Gandikota Venkataramana, Yasutomo Segawa, and Kenichiro Itami Chem. Commun. 2014, 50, 957.
(1) “Synthesis and Properties of [9]Cyclo-1,4-naphthylene: A p-Extended Carbon Nanoring”
Akiko Yagi, Yasutomo Segawa, and Kenichiro Itami J. Am. Chem. Soc. 2012, 134, 2962.
Invited Lectures
(1) 八木亜樹子
『私の歩んできた道』
福島県立会津学鳳中高等学校スーパーサイエンスハイスクール招待講演、福島県立会津学鳳中高等学校、福島、2014年12月
(2) 八木亜樹子
『Synthetic Studies for Novel Hydrocarbon Compounds』
第20回スクリプス・バイオメディカルフォーラム招待講演、メルパルク大阪、大阪、2017年12月
(3) 八木亜樹子
『とある女性研究者の奮闘記』
名古屋大学ジェンダーリサーチライブラリ主催シンポジウム 科学とジェンダー、名古屋大学 2019年11月
5. “アダマンタン縮環芳香族分子の合成と性質”
第14回未来材料セミナー 2023年11月7日
4. “新たな炭素材料創製のための分子合成的アプローチの開拓”
東京大学大学院薬学研究科セミナー 2023年7月11日
3. “新たな炭素材料創製のための分子合成的アプローチの開拓”
関西学院大学村上研究室セミナー 2023年5月23日
2. “新たな炭素材料創製のための分子合成的アプローチの開拓”
産業技術総合研究所 触媒化学融合センター 第96回講演会 2023年4月12日
1. “sp3混成炭素による連結を鍵とした新奇π共役分子の合成”
第54回有機金属若手の会 2022年6月28日
Awards
(11) TBA
(10) The KANTO Chemical Co. Award in Synthetic Organic Chemistry (Oct. 2019)
(9) The 33th Inoue Research Award for Young Scientist (Feb. 2017)
(8) The 6th Otsu Award Fellow (Oct. 2016)
(7) Poster Award (The 26th Symposium on Physical Organic Chemistry, September 2015)
(6) The 9th L’OREAL–UNESCO for Women in Science Japan Fellowships (July 2014)
(5) Poster Award (The 15th International Symposium on Novel Aromatic Compounds (ISNA-15), July 2013)
(4) JSPS Fellowship for Young Scientist (DC1) (April 2013–)
(3) IGER Research Assistant Fellowship (October 2012–March 2013)
(2) Poster Award (The 22th Symposium on Physical Organic Chemistry, September 2011)
(1) President Award (Nagoya University Science Forum for Young Woman Scientists, November 2011)